Oxford+ in Brief with Dr Holly Reeve, co-founder and CEO of HydRegen

What would it take for Oxford to truly unlock its potential as a global innovation hub and what keeps getting in the way?

In this Oxford+ In Brief mini episode, host Susannah de Jager puts four quick-fire questions to Dr Holly Reeve, co-founder and CEO of HydRegen. Holly shares what success looks like if Hydregen reaches commercial scale manufacturing, why Oxford's chemistry department has become a breeding ground for spin-outs, and why she wishes the barriers between universities and startups were far lower than they are today.

With a new super cluster board forming across the Oxford–Cambridge arc and initiatives like Equinox and OX Tech Week working to connect the ecosystem, Holly argues the direction of travel is encouraging. But she is clear that the real bottleneck is not facilities or funding structures: it is the failure to invest strategically in the people behind the science. 

Dr Holly Reeve: Holly Reeve is the co-founder and CEO of HydRegen, an Oxford University spin-out developing bio-based catalysts to replace precious metals in chemical manufacturing. She holds a MChem and DPhil in Inorganic Chemistry from the University of Oxford, where she worked on the HydRegen technologies from inception in Professor Kylie Vincent's research group. Holly has raised over £1.3 million in early-stage funding from Innovate UK and investors, secured a further £2.6 million led by Clean Growth Fund, and grown the company to 15 people. She is a Royal Society of Chemistry Emerging Technology prize winner and a member of the Royal Academy of Engineering Enterprise Hub's Shott Scale Up Accelerator. In June 2025, HydRegen announced a strategic collaboration with James Robinson Speciality Ingredients to implement its Bio2Amine™ biocatalyst technology in commercial manufacturing.

Susannah de Jager: Susannah is a seasoned professional with over 15 years of experience in UK asset management. She has worked closely with industry experts, entrepreneurs, and government officials to shape the conversation around domestic scale-up capital.

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Oxford+ is hosted by Susannah de Jager and supported by Mishcon de Reya, HSBC Innovation Banking, and James Cowper Kreston.

Produced and Edited by Story Ninety-Four in Oxford.