Welcome to Thriving in Midlife: The Women's Guide to Wellness, Longevity & Hormones After 40, your trusted space for women over 40 who want better health, more energy, balanced hormones, and practical wellness strategies that actually work.
I’m your host, Kellie Lupsha, a high-performance health coach, and I’m excited to guide you on a journey toward greater vitality, energy, and well-being.
Did you know that changes associated with Alzheimer’s disease can begin in the brain 20 to 30 years before symptoms appear?
In this episode, Kellie explores the powerful connection between menopause, estrogen, brain health, cognitive function, and Alzheimer’s risk in women.
Menopause is often viewed primarily as a reproductive transition, but estrogen plays important roles in the brain. As estrogen levels fluctuate and decline during perimenopause and menopause, women may experience changes such as brain fog, anxiety, insomnia, memory concerns, and difficulty finding words.
Kellie breaks down why these symptoms deserve attention and why supporting your brain and metabolic health during midlife can be an important part of healthy aging.
What You’ll Learn
*Why menopause can impact brain health
Understand why declining estrogen is connected to changes in brain structure, energy production, cognition, and neurological function.
*Four ways estrogen supports the brain
Learn how estrogen supports mitochondrial function, helps regulate amyloid pathways, supports antioxidant defenses, and helps maintain white matter integrity.
*The connection between estrogen and oxidative stress
Discover how estrogen influences the body's natural antioxidant defenses, including superoxide dismutase (SOD), and why oxidative stress matters for brain health.
*Why genetics are not necessarily your destiny
Explore the role of the APOE gene and why understanding genetic risk can create awareness and encourage proactive lifestyle choices.
*Why your brain health strategy should start now
Learn why your 30s, 40s, and 50s can be important years to focus on metabolic health, exercise, nutrition, sleep, hormones, and other factors that support healthy aging.
Key Takeaways
- Brain health matters long before an Alzheimer’s diagnosis.
- Menopause is more than a reproductive transition. It can also involve significant neurological changes.
- Estrogen has important functions in the brain beyond fertility and reproduction.
- Supporting mitochondrial health and the body's natural antioxidant defenses may be important components of brain health.
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Mentioned in this episode:
2026 Outro with Music
Basic Podcast Intro with Music
