In episode 83 of Going anti-Viral, Dr Steven Grinspoon joins host Dr Michael Saag to provide an update on guidelines for statin use in people with HIV based on results from the REPRIEVE trial. Dr Grinspoon is a Professor of Medicine at Harvard Medical School and a clinician in the Neuroendocrine and Pituitary Tumor Clinical Center and faculty member at the Massachusetts General Hospital. He is a clinical researcher who studies hypothalamic control of body weight and fat distribution in obesity and lipodystrophy with a focus on the metabolic and cardiovascular consequences of visceral fat accumulation. Dr Grinspoon is the author of more than 200 peer-reviewed publications and serves as the chief of the Massachusetts General Metabolism Unit and the director of the Nutrition Obesity Research Center at Harvard. Dr Grinspoon and Dr Saag discuss the latest findings from the REPRIEVE trial and provide updates on statin guidelines for people with HIV as well as providing insights into cardiovascular risk management. They discuss the safety and efficacy of statins and the role of cardiovascular risk calculators in clinical practice in addition to discussing the impact of low-density lipoprotein (LDL) cholesterol and inflammation on cardiovascular risk. Dr Grinspoon also offers his outlook for where further research is needed based on the outcomes of the REPRIEVE trial.
0:00 – Introduction
1:33 – Overview of the REPRIEVE trial findings
2:44 – Changes in statin guidelines for people with HIV
6:51 – Safety and efficacy of statins
9:09 – Use of statins and diabetes risk
11:16 – Cardiovascular risk calculators
16:00 – Statin use and blood pressure
17:14 – Impact of LDL cholesterol and inflammation on cardiovascular risk
24:08 – Future directions in cardiovascular research for people with HIV
Resources:
Going anti-Viral: Episode 56 – Cardiovascular Health in People with HIV – Dr Steven Grinspoon
Apple Podcasts:
https://podcasts.apple.com/us/podcast/the-management-of-cardiovascular-health-in-patients/id1713226144?i=1000725697103
YouTube:
https://youtu.be/297vweZ5bjQ
REPRIEVE Trial:
https://www.reprievetrial.org/
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Produced by IAS-USA, Going anti–Viral is a podcast for clinicians involved in research and care in HIV, its complications, and other viral infections. This podcast is intended as a technical source of information for specialists in this field, but anyone listening will enjoy learning more about the state of modern medicine around viral infections.
Going anti-Viral’s host is Dr Michael Saag, a physician, prominent HIV researcher at the University of Alabama at Birmingham, and volunteer IAS–USA board member. In most episodes, Dr Saag interviews an expert in infectious diseases or emerging pandemics about their area of specialty and current developments in the field. Other episodes are drawn from the IAS–USA vast catalogue of panel discussions, Dialogues, and other audio from various meetings and conferences.
Email podcast@iasusa.org to send feedback, show suggestions, or questions to be answered on a later episode.
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