Recurrent Miscarriage Explained: Genetics, IVF Failure, Hormones & Why Pregnancy Loss Happens

Why does miscarriage keep happening even when everything appears “normal”?

For families navigating recurrent pregnancy loss, the most painful part is often the unanswered questions. Being told it’s “bad luck” or “unexplained” can leave parents feeling confused, frustrated, and searching for deeper answers.

In this powerful and in-depth episode of Cry It Out Loud, we’re joined by reproductive endocrinologist Dr. Ryan Martin to break down the real medical causes behind recurrent miscarriage and the critical factors that are often overlooked.

This is not a surface-level conversation. We go beyond basic explanations and into the complex science of pregnancy loss, helping you understand what may actually be happening in your body. In this episode, we explore:

• When recurrent pregnancy loss should be fully evaluated and whether waiting for multiple miscarriages delays care
• What “chromosomal abnormality” really means, including aneuploidy vs. inherited conditions like balanced translocations
• The role of sperm health and DNA fragmentation in miscarriage and embryo development
• Why miscarriage can still happen after IVF, even with genetically tested embryos (PGT-A)
• Uterine factors that may be missed, including septum, scar tissue (Asherman’s), and fibroids
• How endometriosis and chronic inflammation can impact implantation and early pregnancy
• The truth about immune-related causes of miscarriage, including antiphospholipid syndrome and autoimmune conditions
• The role of progesterone and luteal phase defects in early pregnancy loss
• How thyroid function, insulin resistance, and hormones influence pregnancy outcomes
• The emerging role of epigenetics, stress, and environmental factors
• What “unexplained recurrent pregnancy loss” really means and the limits of current testing
• When to see a reproductive genetic counselor and what advanced testing may provide answers

If you are navigating recurrent miscarriage or pregnancy loss, infertility, IVF failure, or pregnancy loss without clear answers, this episode will give you deeper insight, clarity, and validation.

Your loss is real. Your questions are valid. And you deserve more than “we don’t know why.”

Chasing the Rainbows provides free daily support and resources for families impacted by infertility, miscarriage, stillbirth, and infant loss.

👉 chasingtherainbows.org