2026-09-11 Hosts Craig Lipset and Jane Myles were joined by Becky Kottschade and Dr. Tufia Haddad from the Mayo Clinic to share the evolution of Clinical Trials Beyond Walls, Mayo Clinic’s program for bringing digital and decentralized capabilities into clinical research.

Building on Mayo’s experience with remote patient monitoring, the team started by centralizing capabilities, establishing best practices, and testing new approaches in investigator-initiated trials before scaling more broadly. They discuss the importance of giving participants options for how and where they engage in a trial, what they’ve learned about reaching patients beyond traditional geographic boundaries, and the unexpected growth in participation from rural communities.

The conversation also explores how Mayo is making these capabilities part of its standard trial approach, the challenge of measuring decentralization across studies, and what comes next—including expanding opportunities to involve local healthcare providers in research.

Read their recent publication here -- https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2849940

Follow the Decentralized Trials & Research Alliance (DTRA) on LinkedIn and X. Learn more about Membership options and our work at www.dtra.org.

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