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"Both Our Advice and our Guest Expert insights don't replace your own care team. Always talk to a doctor who can review your personal records and labs to make the safest choices for you."

How GLP-1s Broke Diet Culture

For decades, we believed weight gain and weight loss were mostly about willpower, calories, and exercise. Today, we’re learning there’s much more happening beneath the surface. The biology that drives hunger, metabolism, weight gain, and long-term health is far more complex than we once understood.

In this episode, Dr. Chiadi Ndumele, preventive cardiologist at Johns Hopkins Medicine and a leader with the American Heart Association, explains why GLP-1 medications work, how weight, metabolism, and chronic disease are connected, and why the first-ever Cardiovascular-Kidney-Metabolic (CKM) Clinical Practice Guideline represents a major shift in how we understand and treat weight-related disease. You’ll also hear a powerful patient story that shows why this new understanding is giving hope to millions.

In this episode:

  • Why GLP-1 medications work when diets often don’t.
  • What really drives weight gain, weight loss, and long-term weight management.
  • How metabolism, hormones, genetics, and overall health work together.
  • Why understanding your body can help you advocate for the quality care you deserve.

Guest

Dr. Chiadi Ndumele

  • Preventive Cardiologist, Johns Hopkins Medicine
  • Chair, 2026 American Heart Association/American College of Cardiology Cardiovascular-Kidney-Metabolic (CKM) Clinical Practice Guideline

Resources

American Heart Association: New Cardiovascular-Kidney-Metabolic (CKM) Clinical Practice Guideline
https://www.heart.org/en/news/2026/06/09/new-ckm-guideline-urges-early-weight-talks-to-prevent-health-risks

Professional Heart Daily: 2026 Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome
https://professional.heart.org/en/science-news/2026-guideline-for-the-prevention-detection-evaluation-and-management-of-ckm-syndrome

American Heart Association News Release: First-Ever Clinical Practice Guideline for Cardiovascular-Kidney-Metabolic Syndrome
https://newsroom.heart.org/news/first-ever-guideline-on-cardiovascular-kidney-metabolic-syndrome-issued

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