#84 – When It’s Not SIBO: Mold, Mast Cells, and Chronic Gut Symptoms with Dr. Crane Holmes

What if your gut symptoms aren’t SIBO—and aren’t improving despite treatment?

In this episode, we explore a common clinical scenario: patients with bloating, gas, and digestive issues that look like SIBO but don’t respond to standard therapies. We take a deeper look at mold exposure, mast cell activation, and histamine as overlooked drivers of chronic gut symptoms.

Dr. Crane Holmes joins us to break down how mold can impact the gastrointestinal system, why symptoms often extend beyond the gut, and how to recognize when something more complex is going on.

In this episode, we discuss:

• When to suspect something beyond SIBO
• How mold exposure can drive gut inflammation and symptoms
• The connection between mold, mast cells, and histamine
• Why patients may have multi-system symptoms (brain fog, fatigue, sinus issues)
• The role of environmental testing (ERMI) vs lab testing
• Practical approaches to treatment, including binders, detox support, and reducing exposure

👋 Connect with the Dr. Crane Holmes

⁠https://www.drcraneholmes.com/

👋 Connect with the Turds!

Rebecca Sand ND, LAc, MSOM

• ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.drrebeccasand.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

• ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@drrebeccasand⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Ilana Gurevich ND, FABNG, LAc, MSOM

• ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.openwellnesspdx.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠
• ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@openwellness_pdx⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠
• ⁠⁠⁠⁠⁠⁠@ilana.gurevich⁠⁠⁠⁠⁠⁠

Ami Kapadia, MD, ABFM, ABIHM

• ⁠⁠⁠⁠⁠⁠⁠⁠https://www.amikapadia.com/⁠⁠⁠⁠⁠⁠⁠