Welcome to the Olink® Proteomics in Proximity podcast!
Below are some useful resources mentioned in this episode:
UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date. https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies
Research articles and news
UK Biobank Pharma Proteomics Project Full Cohort Study: Thermo Fisher Scientific’s Olink Platform Selected for World’s Largest Human Proteome Study
https://ir.thermofisher.com/investors/news-events/news/news-details/2025/Thermo-Fisher-Scientifics-Olink-Platform-Selected-for-Worlds-Largest-Human-Proteome-Study/default.aspx
Parabiosis
Conboy et al (2005) Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433: 760-764. https://www.nature.com/articles/nature03260
Villeda et al. (2011). The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 477, 90–94 https://doi.org/10.1038/nature10357
Organ Aging/Ageing Clock Publications leveraging Olink Proteomics
Oh, H.SH et al. (2025). Plasma proteomics links brain and immune system aging with healthspan and longevity. Nat Med 31, 2703–2711. https://doi.org/10.1038/s41591-025-03798-1
Goeminne et al (2025). Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems Cell Metabolism, 37, 205-222.e6
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00401-7
Argentieri, M.A et al. (2024). Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations. Nat Med 30, 2450–2460. https://doi.org/10.1038/s41591-024-03164-7
Young blood factors infused into young mice
Villeda et al (2014). Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature Medicine. 20:659-663. https://www.nature.com/articles/nm.3569
Single cell work with Stephen Quake
Pálovics et al (2022). Molecular hallmarks of heterochronic parabiosis at single-cell resolution. Nature 603:309-314.
https://www.nature.com/articles/s41586-022-04461-2
Andrew Yang, Gladstone Institute labeling of hundreds of endogenous plasma proteins
Yang et al (2020). Physiological blood-brain transport is impaired with age by a shift in transcytosis. Nature 583: 425-430.
https://www.nature.com/articles/s41586-020-2453-z
Eric Topol episode with Tony on Ground Truths
https://erictopol.substack.com/p/tony-wyss-coray-the-science-of-aging
Mike Snyder’s team (Stanford) and the concept of Ageotypes
Ahadi S et al. (2020). Personal aging markers and ageotypes revealed by deep longitudinal profiling. Nature Medicine. 2020;26:83–90. https://www.nature.com/articles/s41591-019-0719-5
Preprint ahead of Nature Medicine paper Tony references coming out weeks after podcast episode
Ding et al (2026; preprint). Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease. bioRxiv
https://www.biorxiv.org/content/10.64898/2026.02.10.704909v1
Vero Biosciences: Founded with Tony where a consumer can have blood measured, which organs show accelerated aging with clinician input into potential interventions. https://www.verobioscience.com/
Teal Rise: Founded with Tony, partnering with Olink that has collected a large database to drive model building across diseases and prediction. https://tealrise.com/
Heike A. Bischoff-Ferrari and the Do-Health Trial:
Bischoff-Ferrari et al (2025). Individual and additive effects of vitamin D, omega-3, and exercise on DNA methylation clocks of biological aging in older adults in the Do-Health trial. Nature Aging. 5: 376-385.
https://www.nature.com/articles/s43587-024-00793-y
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Proteomics in Proximity refers to the principle underlying Olink technology called the Proximity Extension Assay (PEA). More information about the assay and how it works can be found here: https://bit.ly/3Rt7YiY
Host: Cindy Lawley
Co-host: Sarantis Chlamydas
Executive Producer: Cindy Lawley
Editor: Fredrik Hamfelt, Phosworks
Project Manager: Eva Kellerman, Phosworks
For any questions regarding information Olink Proteomics, please email us at info@olink.com or visit our website: https://www.olink.com/
