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Dogs with chronic enteropathy can make even seasoned clinicians feel stuck: antibiotics help, symptoms fade, then everything flares the moment treatment stops. We sit down with Drs. Moshen Hanifeh and Jan Suchodolski to unpack their placebo controlled, double blind trial on oral fecal microbiota transplantation (FMT) in dogs with tylosin responsive enteropathy, a subgroup where relapse after tylosin is a familiar and frustrating pattern. If you’ve been wondering whether “poop capsules” are ready for prime time in veterinary gastroenterology, this conversation gives you the clearest real world framework we’ve heard.
We get specific about what oral FMT actually is, how lyophilized donor feces can be packaged into capsules, and why oral dosing limits may matter in chronic GI disease. Then we dig into the data story clinicians wrestle with every day: measurable microbiome changes, subtle movement in biomarkers, and still no clear, meaningful clinical signal compared with placebo. Along the way, we explore why chronic enteropathy is heterogeneous, how the dysbiosis index functions as a severity marker, and why inflammation markers and dysbiosis do not always track together.
We also translate the findings into practical next steps for treating dogs with TRE right now: stick with therapies that work, prioritize diet management and a thoughtful diagnostic workup, and view oral FMT as promising but not yet a routine standalone option. To close, we map the research roadmap: larger trials, longer follow up, patient stratification by baseline dysbiosis, and comparisons of oral versus enema delivery or combined protocols.
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JAVMA article: https://doi.org/10.2460/javma.26.03.0178
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