Creatine is often associated with the fitness industry and sports performance — but emerging research is now exploring whether it may have relevance far beyond the gym.
In this episode, Anna explores the current evidence surrounding creatine supplementation in Long Covid and fatigue-related conditions, including its potential role in energy metabolism, muscle function, cognitive symptoms, nervous system health, and recovery capacity.
This conversation also looks at:
- Why creatine is being investigated in Long Covid
- The link between ATP production and fatigue
- Potential neuroprotective and antioxidant mechanisms
- Brain fog and cognitive symptoms
- Muscle weakness, PEM, and pacing considerations
- Why individual responses to supplements can vary
- Considerations around dosage, safety, and supplement sensitivity
- Creatine and the menstrual cycle
Importantly, this episode takes a balanced and non-dogmatic approach. While early research is promising, creatine is not presented as a “magic bullet” or standalone solution for Long Covid.
As always, recovery is complex, individual, and multifactorial.
This episode is intended for educational purposes only and should not replace personalised medical advice.
Useful Links
Take the Chronic Fatigue Quiz: https://app.annamarsh.co.uk/quiz-page
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Work with me: https://annamarsh.co.uk/work-together/
Website: https://annamarsh.co.uk/
Referenced Articles
Effects of six-month creatine supplementation on patient- and clinician-reported outcomes, and tissue creatine levels in patients with post-COVID-19 fatigue syndrome
Reduced tissue creatine levels in patients with long COVID-19: A cross-sectional study
Creatine Supplementation in Women’s Health: A Lifespan Perspective
Creatine Supplementation and Brain Health
Diagnostic and Pharmacological Potency of Creatine in Post-Viral Fatigue Syndrome
Role of Creatine Supplementation in Conditions Involving Mitochondrial Dysfunction: A Narrative Review
