In the first PD Exchange podcast episode of 2025, Dr. Nikhil Shah and Dr. Jeff Perl introduce a groundbreaking topic—the ELIXIR trial to evaluate Xylocore, an innovative glucose-sparing solution for peritoneal dialysis. They are joined by experts Dr. Arduino Arduini and Dr. Richard Corbett, who delve into the formulation, rationale, and design of Xylocore, detailing the incorporation of xylitol and carnitine to optimize dialysis outcomes while minimizing glucose exposure. The discussion covers the scientific, clinical, and logistical aspects of the ongoing phase three trial, implications for diabetic patients, and future research directions, emphasizing the potential cardiometabolic benefits and improved patient engagement in PD therapy.
00:00 Introduction to the PD Exchange Podcast
00:54 Meet the Experts: Dr. Arduino Arduini and Dr. Richard Corbett
03:01 The Genesis of Xylocore: A Revolutionary PD Solution
12:11 Clinical Trials and Research Insights
28:05 Patient Engagement and Future Research Directions
33:12 Conclusion and Final Thoughts
PDI Original Article:
Rationale and design of ELIXIR, a randomized, controlled trial to evaluate efficacy and safety of XyloCore, a glucose-sparing solution for peritoneal dialysis
Mario Bonomini
Simon Davies
Werner Kleophas
Mark Lambie
Gianpaolo Reboldi
Lorenzo Di Liberato
Josè Carolino Divino-Filho
Olof Heimburger
Alberto Ortiz
Johan Povlsen
Massimo Iacobelli
Tommaso Prosdocimi
Arduino Arduini
PDI Editorial :
Will Xylocore® be the magic ELIXIR for peritoneal dialysis?
Johann Morelle
Carl M. Öberg
