The ELIXIR Trial and Xylocore Solution: Exploring the Future of Peritoneal Dialysis

In the first PD Exchange podcast episode of 2025, Dr. Nikhil Shah and Dr. Jeff Perl introduce a groundbreaking topic—the ELIXIR trial to evaluate Xylocore, an innovative glucose-sparing solution for peritoneal dialysis. They are joined by experts Dr. Arduino Arduini and Dr. Richard Corbett, who delve into the formulation, rationale, and design of Xylocore, detailing the incorporation of xylitol and carnitine to optimize dialysis outcomes while minimizing glucose exposure. The discussion covers the scientific, clinical, and logistical aspects of the ongoing phase three trial, implications for diabetic patients, and future research directions, emphasizing the potential cardiometabolic benefits and improved patient engagement in PD therapy.

00:00 Introduction to the PD Exchange Podcast

00:54 Meet the Experts: Dr. Arduino Arduini and Dr. Richard Corbett

03:01 The Genesis of Xylocore: A Revolutionary PD Solution

12:11 Clinical Trials and Research Insights

28:05 Patient Engagement and Future Research Directions

33:12 Conclusion and Final Thoughts

PDI Original Article:

Rationale and design of ELIXIR, a randomized, controlled trial to evaluate efficacy and safety of XyloCore, a glucose-sparing solution for peritoneal dialysis

Mario Bonomini

Simon Davies

Werner Kleophas

Mark Lambie

Gianpaolo Reboldi

Lorenzo Di Liberato

Josè Carolino Divino-Filho

Olof Heimburger

Alberto Ortiz

Johan Povlsen

Massimo Iacobelli

Tommaso Prosdocimi

Arduino Arduini

PDI Editorial :

Will Xylocore® be the magic ELIXIR for peritoneal dialysis?

Johann Morelle

Carl M. Öberg