Karl Pfleger is the founder of agingbiotech.info and an investor in several rejuvenation startups. Topics we discuss are well captured by the timestamps below. Watch on YouTube or X. Listen on Apple Podcasts, Spotify, or any other podcast platform. Follow me on X for updates on future episodes. Timestamps 0:00 - Why lifespan is the wrong metric for aging progress 7:28 - Is the hallmarks of aging expanding a problem? 11:36 - Structures vs. processes: the key distinction in aging targets 16:14 - Why Karl favors divide-and-conquer rejuvenation over slowing aging 22:07 - Whole-body replacement and organ/cell-level rejuvenation 26:56 - Is partial epigenetic reprogramming the kill-shot for aging? 35:24 - CMLase and reversing crosslink damage 40:57 - Can AI just solve aging automatically? 46:57 - Funding misallocation and the case for more aging biotech companies/VC 57:28 - Objections to eliminating aging — and why none hold up 1:01:27 - Karl critiques Bryan Johnson’s “Don’t Die” This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.arjunkhemani.com Rss Apple Podcaster →
