Episode: 43 - Overcoming the Deadlock in Patient Recruitment With Christine Senn

For decades, clinical trial recruitment has been the biggest challenge in the industry. Christine Senn, senior vice president of Site-Sponsor Innovation at Advarra, offers insights into why the struggle continues, such as delays in getting regulations updated after a quarter of a century, and how to overcome the deadlock in clinical trial recruitment that is tied to current obsolete marketing guidelines. Also, host Deborah Borfitz shares the latest on beta blockers, low dose aspirin lowering the risk of recurring colorectal cancer, repurposing drugs for breast cancer relapse prevention, remote participation research on why athletes and military members face higher ALS risk, and the first agentic AI platform for life sciences from Medable. 

Show Notes 

News Roundup 

Rethinking beta blockers 

• Press release on the Mount Sinai website 
• Subgroup analysis study in the European Heart Journal 

Aspirin lowers risk of colorectal cancer recurrence 

• Study in The New England Journal of Medicine  

CLEVER study to prevent breast cancer relapse 

• Study in Nature Medicine 
• News release on Penn Medicine website   

Champion Insights ALS initiative 

• News release on Answer ALS website 

Medable’s Agent Studio 

• Press release on the Medable website 

Disseminating research findings 

• Systematic review in PLOS Medicine  

Guest 

Christine Senn, Ph.D., senior vice president of site-sponsor innovation at Advarra 

The Scope of Things podcast explores clinical research and its possibilities, promise, and pitfalls. Clinical Research News senior writer, Deborah Borfitz, welcomes guests who are visionaries closest to the topics, but who can still see past their piece of the puzzle. Focusing on game-changing trends and out-of-the-box operational approaches in the clinical research field, the Scope of Things podcast is your no-nonsense, insider’s look at clinical research today.