Join us for another episode in our Tools for Looking into the Brain series, where we learn about methods used to understand the nervous system from experts in the field. This week we are joined by Dr Paula Pousinha, a neuroscientist and associate professor at Université Côte d’Azur who researches the neurobiological mechanisms that underlie brain ageing and neurodegenerative diseases. Paula tells us how we can use rodent models to understand the neural mechanisms that lead up to Alzheimer's disease, and in particular how neuronal firing and physiological properties gradually change alongside changes in synapses and connectivity. We also discuss bridging the gap between single neurons and cognition, what defines excitability, how similar approaches can be used to tackle several neurodegenerative disorders, and how this knowledge can shape future therapies to treat neurodegenerative disorders.
Dr. Paula Pousinha is a neuroscientist and Associate Professor of Physiology at Université Côte d’Azur in Nice, France. Paula earned a PhD in Biomedical Sciences from the University of Lisbon, then completed a postdoctoral fellowship in the lab of Hélène Marie at the Institute of Molecular and Cellular Pharmacology in France where she investigated how synaptic plasticity and neuronal activity change during ageing and contribute to cognitive decline. Her lab's current research focuses on the synaptic and circuit mechanisms that underlie brain ageing and neurodegenerative diseases, particularly Alzheimer’s disease.
This episode is part of our Tools for Looking into the Brain series which is sponsored by Scientifica, leaders in electrophysiological equipment and expertise. This series is dedicated to creating engaging and informative content exploring various techniques used by researchers in neuroscience. Find out more here.
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