In this episode of The Healthtech Podcast, James is joined by Steve Bulera, Chief Scientific Officer for Safety Assessment and Toxicology at Charles River Laboratories — one of the world's largest CROs, and a company that almost every new drug passes through on its way from lab to human trials. They dig into one of the most significant shifts in preclinical drug development: the move away from traditional animal testing towards virtual control groups, AI-assisted decision-making, and what Steve calls "new approach methodologies." It's a candid conversation about where the science is, why the regulators are cautious, and what it actually takes to change a decades-old industry from within.
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