In this episode of Resiliency Radio with Dr. Jill, Dr. Jill Carnahan sits down with researcher and collaboration architect Nikki Schultek to explore an often-overlooked contributor to chronic disease: persistent infections and their impact on inflammation, immunity, and the brain.
Drawing from her own experience with severe chronic illness, Lyme disease, Chlamydia pneumoniae, and autoimmunity, Nikki shares how her personal health journey led her into research and a mission to connect scientific disciplines that too often operate in isolation.
Together, they explore the emerging concept of the pathobiome, the potential infectious drivers of Alzheimer's and other neurodegenerative diseases, the challenges of diagnosing persistent infections, and why understanding the body as an interconnected ecosystem could transform the future of chronic illness research and treatment.
🔑 5 Key Discussions
① 🦠 Chronic Infections as Hidden Drivers of Disease
⇨ Persistent infections may play an overlooked role in autoimmune disease, chronic fatigue, asthma, neurological illness, and other complex chronic conditions.
⇨ Pathogens including Lyme-associated organisms, Chlamydia pneumoniae, Mycoplasma, Epstein-Barr virus, Bartonella, and Babesia may persist or reactivate under certain conditions rather than behaving solely as short-lived infections.
② 🧠 The Brain Is Part of a Larger Ecosystem
⇨ Brain health cannot be separated from immune function, systemic inflammation, the gut, environmental exposures, and infectious burden.
⇨ Emerging research challenges the traditional view of the brain as an isolated, sterile environment and raises important questions about microbes, immune activity, and chronic neuroinflammation.
③ 🔬 Rethinking Alzheimer's & Neurodegeneration
⇨ Researchers are investigating whether infections and immune responses may contribute to diseases such as Alzheimer's and Multiple Sclerosis.
⇨ The Alzheimer's Pathobiome Initiative is bringing researchers together to investigate whether amyloid plaques, tau changes, and other features of neurodegeneration may be connected to microbial activity and the body's response to infection.
④ 🧬 Understanding the Pathobiome
⇨ The pathobiome expands beyond simply identifying which microorganisms are present—it considers the relationship between microbes, the host immune system, hormones, environmental exposures, and the body's overall terrain.
⇨ Disease may emerge when changes in this ecosystem allow normally controlled or latent organisms to proliferate, reactivate, or provoke damaging immune responses.
⑤ 🤝 Building a New Model for Chronic Illness Research
⇨ Complex illnesses rarely fit neatly into one medical specialty, making collaboration between immunologists, neurologists, infectious disease researchers, clinicians, and other experts essential.
⇨ Nikki's work as a collaboration architect focuses on breaking down scientific silos and accelerating the translation of emerging research into meaningful clinical understanding.
⭐ Key Takeaways
🔹 Chronic infections may be important but frequently overlooked contributors to complex chronic illness.
🔹 Brain inflammation can be influenced by immune dysfunction and processes occurring throughout the body.
🔹 Chlamydia pneumoniae and other atypical pathogens deserve greater attention when investigating persistent illness.
🔹 Current testing may not always clearly distinguish between historical exposure and clinically relevant persistent infection.
🔹 COVID-19 may disrupt immune function and potentially contribute to the reactivation of latent infections.
🔹 The pathobiome provides a broader framework for understanding interactions between microbes, immunity, environment, and disease.
🔹 Infectious and immune mechanisms are increasingly being investigated in Alzheimer's and other neurodegenerative conditions.
🔹 Collaboration across scientific disciplines will be critical for advancing research into complex chronic disease.
👩🔬 Guest Biography
Nikki Schultek is the Executive Director of the Alzheimer's Pathobiome Initiative (AlzPI), Principal Founder of Intracell Research Group, LLC, and Founding Director of the Pathobiome Research Center at the Philadelphia College of Osteopathic Medicine (PCOM).
After earning a BS in Business Administration from Villanova University, Nikki began her career with Pfizer and Genentech. Her professional direction changed following her own recovery from Lyme disease and other chronic infections, inspiring her to focus on advancing research into infection-associated chronic illnesses, including Alzheimer's disease, PANDAS/PANS, and asthma.
Since founding Intracell Research Group in 2017, Nikki has built global collaborations connecting researchers, clinicians, academic institutions, and other stakeholders. She is also a co-investigator on the 3,200-patient iTREAT-PC asthma clinical trial and serves on the Board of Directors of the International Lyme and Associated Diseases Education Foundation.
Nikki has helped secure philanthropic funding to launch AlzPI research across eight academic centers and co-led the development of a research roadmap published in Alzheimer's & Dementia in 2023. Her work is helping advance rigorous investigation into the potential role of microbial infections in Alzheimer's disease, dementia, and other brain disorders.
🌐 Connect & Learn More
🔗 Alzheimer's Pathobiome Initiative: https://www.alzpi.org/
🔗 Intracell Research Group: https://www.intracellresearchgroup.com/
🔗 Pathobiome Research Center at PCOM: https://www.pcom.edu/research/pbrc/
🔬 Current Mission
The global consortium is working to secure funding to fully operationalize its international research collaboration and accelerate investigation into the role infections may play in Alzheimer's disease and other brain diseases.
