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What if cognitive decline is not as inevitable as we have been told?
In this episode of the Longevity & Lifestyle Podcast, I welcome back Dr. Dale Bredesen, internationally recognized neurologist, bestselling author, and pioneer in the prevention and reversal of cognitive decline.
Dr. Bredesen shares the findings from his latest randomized controlled trial, in which 90% of participants receiving a precision medicine protocol improved. We explore why Alzheimer’s may begin decades before symptoms appear, the biomarkers that can help identify risk earlier, and the lifestyle and medical factors that may influence cognitive health.
We also discuss the role of sleep, insulin resistance, inflammation, toxins, ketones, peptides, stem cells, GLP-1 medications, psychedelics, and neuroplasticity.
This conversation offers an important message: the earlier we understand what is driving cognitive decline, the greater the opportunity to act.
In this episode, you’ll learn:
• Why Alzheimer’s may begin decades before symptoms
• What Dr. Bredesen’s latest trial revealed
• The stages from prevention to dementia
• Blood biomarkers linked to early decline
• Insulin resistance, ketones, and brain energy
• Sleep apnea and long-term brain health
• Why there is no single cure
TIMESTAMPS
00:00 Introduction
03:37 The Alzheimer’s trial where 90% improved
06:35 What drives cognitive decline
12:01 Why Alzheimer’s is no longer viewed as hopeless
16:08 The four stages of cognitive decline
18:22 Blood tests that may reveal risk earlier
22:22 The key drivers of Alzheimer’s
23:36 The seven foundations of brain health
25:53 Sleep targets for cognitive longevity
28:27 GLP-1s and Alzheimer’s risk
31:35 Peptides for brain health
35:59 Stem cells, exosomes, and regenerative medicine
39:32 Is there hope at every stage?
40:45 Inside the randomized clinical trial
46:18 Psychedelics and neuroplasticity
52:31 Dr. Bredesen’s final message
CONNECT WITH DR. DALE BREDESEN
Website: https://www.drbredesen.com
Free cognitive assessment: https://www.mycqtest.com
Brain biomarker testing: https://www.getabrainscan.com
CONNECT WITH CLAUDIA
Website: https://longevity-and-lifestyle.com
Instagram: https://www.instagram.com/longevityandlifestyle
LinkedIn: https://www.linkedin.com/in/claudiavonboeselager
YouTube: https://www.youtube.com/@LongevityandLifestyle
Subscribe to the Longevity & Lifestyle Podcast for more conversations with leading scientists, physicians, founders, and innovators shaping the future of health and human performance.
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