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What if we could improve tendon healing by manipulating the immune system, injecting ozone, or even exposing the tendon to specific wavelengths of light?
In this episode of the Overcoming Proximal Hamstring Tendinopathy Podcast, Brodie explores three emerging areas of tendon research that sound futuristic—but are already producing some fascinating early results.
Most of this research is still preclinical, so this isn't an episode about treatments you should rush out and try. Instead, we look at what scientists are discovering about tendon healing, how convincing the evidence currently is, and whether these approaches could eventually have a role in treating stubborn conditions like PHT.
In this episode:
- Immune therapy & “smart scaffolds”
- Why inflammation isn't necessarily the enemy during tendon healing
- How researchers are developing hydrogels and scaffolds that can respond to the tendon environment
- The potential role of exosomes in regulating inflammation and collagen repair
- Why this technology is fascinating—but still a long way from routine PHT treatment
- Oxygen–ozone therapy
- What an ozone injection actually is
- How a small amount of oxidative stress may trigger a beneficial biological response
- A striking tennis-elbow study where 92.8% of the ozone group had favourable resting-pain outcomes at nine months, compared with 39.5% following corticosteroid
- What animal research suggests about ozone and tendon strength
- Why the evidence is still too limited to recommend it for PHT
- Photobiomodulation / light therapy
- How red and near-infrared light may influence the mitochondria inside tendon cells
- Why different wavelengths and doses matter
- Animal research showing approximately:
- 40% lower inflammatory markers
- 65% greater markers associated with inflammation resolution
- 1.7Ă— better type-I-to-type-III collagen ratio
- 20% greater tendon tensile strength
- Why these impressive laboratory results don't yet mean you should buy a red-light device for PHT
The key message:
These treatments all approach tendon healing differently, but they share an important idea: future tendinopathy treatment may involve improving the biological environment of the tendon alongside progressive rehabilitation.
For now, there isn't enough evidence to recommend any of these approaches specifically for proximal hamstring tendinopathy.
So while researchers continue exploring the weird and wonderful future of tendon healing, stick with the fundamentals that we know work: appropriate load management, progressive strengthening and gradually rebuilding tendon capacity.
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MEDICAL & EDUCATIONAL DISCLAIMER
The information provided in the Overcoming Proximal Hamstring Tendinopathy (PHT) Podcast, YouTube channel, associated websites, social media, and other educational content produced by Brodie Sharpe is provided for general educational and informational purposes only. It is not intended to constitute, and should not be relied upon as, individual medical, physiotherapy, diagnostic or treatment advice.
Although Brodie Sharpe is a qualified physiotherapist, consuming this content does not establish a physiotherapist-patient or other healthcare professional-patient relationship. Any discussion of symptoms, diagnoses, rehabilitation strategies, exercises, loading programs, running modification, medications, supplements, injections, medical procedures or other treatment options is general in nature and may not be appropriate for your individual circumstances.
Musculoskeletal pain can have multiple causes, and symptoms that appear consistent with proximal hamstring tendinopathy or another tendon disorder may arise from other conditions. Appropriate assessment, diagnosis and treatment depend upon an individual's medical history, symptoms, examination findings, medications, health conditions, training history and other factors that cannot be adequately assessed through general online content.
Do not use this content as a substitute for assessment, diagnosis or treatment from an appropriately qualified healthcare professional.Â
Before starting, stopping or substantially modifying an exercise or rehabilitation program, medication, supplement, injection, procedure or other treatment discussed in this content, seek advice from an appropriately qualified healthcare professional who can consider your individual circumstances.
Exercise, rehabilitation and medical treatments carry inherent risks. These may include increased pain, symptom flare-ups, aggravation of an existing condition, new injury, adverse reactions or other complications. Individual responses vary and no particular outcome, improvement, recovery timeframe or return to sport can be guaranteed. If an activity or intervention causes significant, unusual or worsening symptoms, stop and seek appropriate professional advice.
References to research, clinical studies, treatment approaches, products or opinions of guests are provided for educational purposes. Scientific evidence evolves over time, may be incomplete or conflicting, and findings from research populations may not apply to every individual. Discussion of a treatment or product does not necessarily constitute an endorsement or recommendation for its use. Views expressed by podcast guests or other contributors are their own and do not necessarily represent the views of Brodie Sharpe.
To the extent permitted by applicable law, Brodie Sharpe and associated businesses, contractors and contributors accept no liability for loss, injury, damage or adverse outcomes arising from reliance upon or use of this general educational content. Nothing in this disclaimer is intended to exclude, restrict or modify any right, guarantee, remedy or liability that cannot lawfully be excluded, restricted or modified under applicable law.
If you believe you may have a serious injury or medical condition, or you develop severe, rapidly worsening or otherwise concerning symptoms, seek prompt assessment from an appropriately qualified healthcare professional. In an emergency, contact your local emergency service.
