Why do around 30% of people with epilepsy still have uncontrolled seizures despite decades of new antiseizure medications? Graeme Sills, PhD, explains the leading theories behind drug resistance - and how a better understanding of the brain could transform future epilepsy treatments.

Chapters 📖
00:00 Trailer & intro
00:45 Meet Graeme Sills
01:29 Introduction to pharmacology and epilepsy
02:17 Challenges in epilepsy reatment
06:30 Why the drugs don’t work: the drug-transporter hypothesis
08:38 Why the drugs don’t work: the network hypothesis
09:31 Why the drugs don’t work: the severity and genetic hypothesis
10:06 Future directions in epilepsy research
13:08 Innovative approaches to research and treatment?
17:58 Closing thoughts & thanks

🔗 Episode page and transcript epilepsysparks.com/epilepsy-sparks-insights/pharmacology-past-present-future

🌐 More about Graeme epilepsysparks.com/guests/graeme-sills

🌐 More Epilepsy Sparks Insights epilepsysparks.com/epilepsy-sparks-insights

🎥 Watch on YouTube youtube.com/@EpilepsySparksInsights

🔤 Don’t understand terms used? Check out the Epilepsy Sparks Glossary epilepsysparks.com/glossary

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