Covid-19 Vaccines Trials and Press Releases – Looking Beyond the Efficacy - 5 - Precision Evidence | Lyssna här

Results from clinical trials should be published in medical papers and not evaluated from selected information in press releases
We still need a lot of information from the trials to be able to have a clear picture of the efficacy and safety of the Covid-19 vaccines, let alone the precision and clinical relevance of the findings
The information presented in the press releases are not sufficient to make calculations on risk
But here is what you can find if you do it anyway

GET THE ABSTRACT SCREENING TOOL

It can be a challenge to screen papers for clinical relevance. As we go beyond the abstract in this podcast, we have created a screening tool you can use when reading an abstract from a clinical research paper.

Using that tool enables you to quickly screen an abstract from a medical journal for clinical relevance selecting only those you want to read. At the same time, you will know why you skipped the rest. Get it at https://www.precision-evidence.com/tool

LINKS:

Table with estimates of how many people need to be vaccinated to prevent one case of covid-19 https://www.precision-evidence.com/blog/how-many-people-need-to-be-vaccinated-to-prevent-one-case-of-covid-19/

Precision Evidence Matrix https://precision-evidence.com/matrix

NOTES:

We only have limited information about the new Covid-19 vaccines released by press releases

Unfortunately, there is a broad misunderstanding of how to interpret the efficacy measures and what they mean
What is an efficacy value, and what can we learn from that?
We only have the raw measures of efficacy without confidence intervals
Efficacy versus efficiency and why it matters
Based on data from the press releases, we cannot make a valid calculation of how many people need to be vaccinated to prevent one case of covid-19
But we do it anyway…
Estimating how many people need to be vaccinated to prevent one case of covid-19 based on the data we have (the Number Needed to Treat or NNT values)
Are these values good?
Finding clinical relevance and meaningfulness with using the Precision Evidence Matrix
Press releases versus future medical papers
What are we missing?
Comparison between different vaccine trials
We will follow up when the research papers are published

Twitter @PrecisionEBM,

website: www.precision-evidence.com

Hosts:

Dr. Kim Kristiansen, M.D: @KKristiansenMD

JG Staal: @HealthyEvidence

Music thanks to mixkit.co

Rss Apple Podcaster