How AI-Based Bioreactors Can Improve Enzyme Production

Researchers have developed a new sensor-enabled bioreactor that uses machine learning technology for improved enzyme production. This advanced technology—created by researchers at Iowa State University and Novonesis, with funding by BioMADE—pairs continuous monitoring with AI-guided control to give manufacturers a faster, more precise way to manage enzyme production.

In this episode of Off Script, we connected with Mike Hess, senior regional technology manager at Novonesis, and David Nathan, program director at BioMADE, to discuss the development of the new bioreactor and how real-time monitoring and AI-based control help manufacturers automate previously manual processes, improve batch consistency, and ultimately accelerate the path to market. The conversation also explored how the project led to the development of low-cost bioreactors that researchers are now working to turn into hands-on bioprocessing educational kits for students.