Mendelian Randomisation

In this episode, Chloe Burke and Saba Ishrat introduce you to the basics of Mendelian Randomisation. They talk about how and why Mendelian Randomisation is used in addiction research to look at causal relationships, as well as its limitations.

They speak to two experts in the field. First, Dr Anya Topiwala talks about her experiences of using Mendelian Randomisation, including research assessing the relationship between drinking and telomere length. And second, to Dr Robyn Wootton who talks about using Mendelian Randomisation in studying the relationship between mental health and substance use. The second interview also covers the potential pitfalls of Mendelian Randomisation, and some practical tips to avoid them.

Chloe and Saba have compiled a selection of open-access links below:

• Assessing and addressing collider bias in addiction research: the curious case of smoking and COVID-19. By Harry Tattan-Birch and colleagues. Published in Addiction (2020).
• Assessing causal relationships using genetic proxies for exposures: an introduction to Mendelian randomization. By Srinivasa Vittal Katikireddi and colleagues. Published in Addiction (2017).
• Mendelian randomisation for psychiatry: how does it work, and what can it tell us? By Robyn E. Wootton and colleagues. Published in Molecular Psychiatry (2022).
• Making sense of Mendelian randomisation and its use in health research: A short overview. By Sean Harrison and colleagues. Published by Public Health Wales NHS Trust & Bristol University.
• MR Dictionary. Published by University of Bristol. 

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