ASCO 2026 Updates in Metastatic Breast Cancer

In this podcast episode, Hope S. Rugo, MD, FASCO, and Nerea Lopetegui-Lia, MD, discuss practice-informing data presented at ASCO 2026 for patients with metastatic breast cancer, including:

• Findings from SERENA-6 on ctDNA-guided treatment switching for emergent ESR1 mutations before radiographic progression, including updated PFS2 and downstream treatment outcomes
• Emerging precision strategies in HR-positive/HER2-negative advanced breast cancer from ELEVATE and PIKALO-1, including elacestrant plus capivasertib and mutant-selective PI3Kα inhibition with tersolisib
• First-line TROP2-directed ADC data from ASCENT-04, ASCENT-03, and TROPION-Breast02, with discussion of PFS2, subsequent therapy, immunotherapy eligibility, and treatment sequencing

Presenters: 
Hope S. Rugo, MD, FASCO  
Director, Women’s Cancer Program 
Division Chief, Breast Medical Oncology 
Professor, Department of Medical Oncology & Therapeutics Research 
City of Hope Comprehensive Cancer Center 
Professor Emeritus and Emeritus Winterhof Family Distinguished Professor of Breast Oncology 
University of California, San Francisco 
San Francisco, California 

Nerea Lopetegui-Lia, MD 
Assistant Professor 
Division of Medical Oncology, Breast Section 
Department of Internal Medicine 
The Ohio State University 
Columbus, Ohio 

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Link to full program:
https://bit.ly/4x4u5AT

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