Dr. Joseph Kim solved cryo-EM structures of mu and kappa opioid receptors bound to the same small molecule — and found it does something different at each one.
In this conversation, Dr. Kim walks through his transition from cryo-electron tomography to GPCR structural biology in Ashish Manglik's lab at UCSF, the strategy behind solving inactive-state receptor structures, and why his favorite GPCR — the galanin receptor — has resisted every small-molecule screen thrown at it.
Key takeaways:
How one molecule acts as an antagonist at mu and an inverse agonist at kappa
Why the galanin receptor's peptide binding mode blocks conventional drug discovery
What it takes to switch fields with no prior biochemistry training
How building tools on "vanilla" GPCRs prepares you for exotic targets
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