Build Aerobic Fitness Before Mitochondrial Peptides: AMPK, VO2 Max & Recovery — Dr. Dwayne Jackson — #400

Dr. Dwayne Jackson is a health specialist, medical educator, scientist, and entrepreneur with a PhD in neurovascular physiology.

Mitochondrial peptides may be promising, but they cannot replace the aerobic base that makes their effects measurable. Dr. Dwayne Jackson explains AMPK and mitochondrial signaling, what MOTS-c and SS-31 can and cannot tell us, and why fitness data, training, and recovery come before any experimental compound.

Expect to learn how aerobic fitness supports strength and Strongman training, why lactate clearance and conditioning can become the rate limiter, what AMPK and mTOR signal, how kidney disease changed Dwayne’s perspective on aerobic capacity, where the evidence for MOTS-c and SS-31 is limited, how to design a more useful N-of-1 experiment, and why training, nutrition, recovery, COAs, and third-party testing come before experimental compounds.

Connect with Dwayne:

• Website: drdwaynejackson.com
• Google Scholar

Episodes you’ll enjoy next:

• #396 — Are Your Peptides Illegal? — Rick Collins: A practical look at peptide science, regulation, and the gray market.
• #393 — From Powerlifter to Trail Runner — Paul Oneid & Cody Miller: VO2 max, cardiac adaptations, and the transition from strength sports to endurance.

Episode Timestamps:

• 01:53 — Mitochondrial peptides and the aerobic-training foundation
• 03:19 — Peptides as training amplifiers, not replacements
• 04:22 — AMPK, mTOR and mitochondrial signaling
• 05:50 — Why aerobic fitness supports strength and Strongman training
• 08:12 — Conditioning, lactate clearance and the rate limiter for strength athletes
• 10:58 — Wingate tests and overlapping energy systems
• 15:12 — Kidney disease, mitochondrial dysfunction and aerobic collapse
• 21:22 — Hypertensive crisis, dialysis and recognizing a major fitness decline
• 24:48 — Kidney transplant recovery and rebuilding aerobic capacity
• 28:27 — The evidence and limitations behind mitochondrial peptides
• 34:55 — MOTS-c, AMPK activation and anecdotal HIIT performance
• 39:59 — SS-31, cardiolipin and mitochondrial efficiency
• 48:32 — Why training, nutrition and recovery come before peptides
• 58:40 — Using performance data to make an N-of-1 experiment more useful
• 1:01:22 — SS-31 before training, AMPK timing and recovery trade-offs
• 1:06:07 — SLU-PP-332, exercise mimetics and the gap in human data
• 1:09:17 — Peptide sourcing, COAs and third-party testing
• 1:12:02 — Genetics, response variability and sustainable performance

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