Semaglutide, tirzepatide and retatrutide are often spoken about as though they are simply different versions of the same thing.
They are not—and Kim Constable’s personal experience with each one was very different.
In this episode, Kim moves beyond receptor science and shares what exploring all three compounds was actually like for her: the benefits she noticed, the side effects she experienced, the results that surprised her and which option she personally preferred.
Kim’s interest in GLP-1s originally extended far beyond weight loss.
As she moved further into menopause, she was struggling with persistent gluteal tendinopathy, joint pain, digestive discomfort, bloating, morning headaches, brain fog, broken sleep and repeated nighttime bathroom trips. Foods she had eaten comfortably for years—including beans, lentils and cruciferous vegetables—had become increasingly difficult to tolerate.
After hearing GLP-1s discussed in relation to inflammation, digestion, sleep and metabolic health, Kim began exploring semaglutide. She later tried tirzepatide and retatrutide, allowing her to compare her personal response to all three.
The compounds target different combinations of pathways:
• Semaglutide primarily targets GLP-1
• Tirzepatide targets GLP-1 and GIP
• Retatrutide targets GLP-1, GIP and glucagon
Kim explains why those differences matter and why a compound that feels transformative for one person may feel far less effective—or create more unwanted effects—for another.
Inside this episode:
• Why Kim first became interested in GLP-1s during menopause
• The difference between semaglutide, tirzepatide and retatrutide
• Why more receptor activity does not automatically mean better results
• Kim’s personal experiences with appetite and food noise
• The differences she noticed in inflammation and physical pain
• Changes she observed in digestion, headaches, brain fog and sleep
• How each experience affected fat loss and weight maintenance
• Why she initially felt hesitant to admit that easier fat loss appealed to her
• The judgment surrounding GLP use
• Fatigue, headaches and digestive slowing
• An unexpected herpes flare-up pattern Kim noticed while taking semaglutide
• Why anecdotal observations do not prove clinical causation
• The benefits that felt meaningful to Kim and the effects that did not
• Which of the three she personally preferred
• Why another person’s experience or dose should never become your protocol
This episode is not intended to tell listeners which compound they should choose. It is a candid account of Kim’s individual experience with three different compounds and why she believes the decision is far more nuanced than simply asking which one is “strongest.”
This episode contains candid discussion of genital herpes, digestive symptoms and medication side effects.
Kim’s experience is personal. Nothing discussed should be treated as proof that another person will experience the same benefits, risks or side effects.
This podcast is for educational and informational purposes only. Kim is not a doctor or licensed medical practitioner. Nothing in this episode should be interpreted as medical advice, a diagnosis, prescribing guidance or instructions for purchasing, reconstituting, dosing or administering any compound.
Always consult an appropriately qualified healthcare professional before beginning, stopping or changing any medication or treatment. Some compounds discussed may be prescription medicines or investigational products depending on jurisdiction and current regulatory status.
✨ Follow Kim Constable online for more real talk and daily motivation:
📺 YouTube: https://www.youtube.com/@besculptedbykim
📸 Instagram: https://www.instagram.com/thesculptedvegan
🎵 TikTok: https://www.tiktok.com/@kimconstableofficial
🌐 Website: https://www.thesculptedvegan.com
