What is it?

  • Colorectal cancer
  • 3rd most diagnosed cancer in US (men & women)
  • S/S = blood in stool, GI irritation, irregular stools, chronic diarrhea, sudden weight loss
  • Diagnostic = colonoscopy – polyps, inflammation, ulcers, abnormal growths
  • ACS testing guidelines
    • Asymptomatic, negative family history, no polyps – every 10 years
    • Low-risk polyps – 5 years
    • High-risk polyps

What causes it?

  • Cause
    • Age (90% of cases for people > 50 y/o)
    • Family history
    • Race – African Americans (new Dx 20% higher in Blacks, and death rates 40% higher)
    • Ethnicity – Ashkenazi Jews
    • Ulcerative colitis, Crohn’s disease
    • Low whole grain diets
    • Genetic predisposition
    • Smoking, alcohol use, lack of exercise, diabetes

How is it treated?

  • Stage O, I -- Sx
  • Stage II – Sx + Adj Chemo
  • Stage III – Sx + Adj Chemo
  • Stage IV – Sx + Chemo
    • Chemo + Targeted Tx
    • Gene types – + immunotherapy
    • Radiation

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