Pro Pharma Talks

What is it?

Colorectal cancer

3rd most diagnosed cancer in US (men & women)

S/S = blood in stool, GI irritation, irregular stools, chronic diarrhea, sudden weight loss

Diagnostic = colonoscopy – polyps, inflammation, ulcers, abnormal growths

ACS testing guidelines

Asymptomatic, negative family history, no polyps – every 10 years

Low-risk polyps – 5 years

High-risk polyps

What causes it?

Cause

Age (90% of cases for people > 50 y/o)

Family history

Race – African Americans (new Dx 20% higher in Blacks, and death rates 40% higher)

Ethnicity – Ashkenazi Jews

Ulcerative colitis, Crohn’s disease

Low whole grain diets

Genetic predisposition

Smoking, alcohol use, lack of exercise, diabetes

How is it treated?

Stage O, I -- Sx

Stage II – Sx + Adj Chemo

Stage III – Sx + Adj Chemo

Stage IV – Sx + Chemo

Chemo + Targeted Tx

Gene types – + immunotherapy

Radiation

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