A low dose of tirzepatide, taken purely to move the needle on cholesterol, turned out to move a lot more than that. In this episode, Jeff sits down again with Dr. Robin Berzin, founder of Parsley Health, to go through his bloodwork and an unexpected side effect: a blunting of desire that shows up in his coffee, his cocktails, and his ambition.
Why losing your appetite for food can also mean losing it for coffee, alcohol, and sex
What the dopamine and serotonin circuitry are actually doing on a GLP-1
The line between healthy desire and maladaptive craving, and where these drugs land on it
Why some people feel liberated when "food noise" disappears, and others feel flattened
What Jeff's ApoB and LDL numbers say about who these drugs actually help
This episode is for anyone on a GLP-1 or weighing one, and anyone curious what these drugs are doing beyond the scale.
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