"The same medication, the same dose—but given at bedtime improved efficacy by 150%."
Does the timing of a medication influence how well it works?
In this episode of JCMS Author Interviews, Dr. Kirk Barber speaks with Dr. Elena Netchiporouk, Assistant Professor of Medicine at McGill University and attending dermatologist at the McGill University Health Centre, about the emerging science of chronotherapeutics.
Dr. Netchiporouk explains how the body's circadian rhythms influence inflammation, immune responses, skin barrier repair, and wound healing. She discusses evidence suggesting that timing therapies to coincide with these biological cycles may improve treatment outcomes for inflammatory skin diseases, including atopic dermatitis, psoriasis, and chronic spontaneous urticaria.
The conversation explores practical implications for commonly used therapies such as methotrexate, cyclosporine, JAK inhibitors, and topical corticosteroids, while highlighting an exciting and underexplored area of dermatology that may help clinicians optimize both efficacy and tolerability.
Read the article: "Time-Driven Strategies for Inflammatory Skin Diseases: A Circadian Approach" in the Journal of Cutaneous Medicine and Surgery.
Dr. Barber and his guests do not receive any financial reimbursement for the production of this podcast.
For more great CDA podcasts check out Dermalogues, our Residents podcast hosted by Dr Kerri Purdy.
To learn more about the work of the Canadian Dermatology Association, please visit our website at dermatology.ca
This podcast is produced by David McGuffin and Graham McGuffin of ExploreProductions.ca
