TWiV 1374: Clinical Update with Dr. Daniel Griffin

In his weekly clinical update, Daniel Griffin and Vincent Racaniello discuss the identification of a type 1 poliovirus outbreak in Syria, the loss of US measles elimination status, use of the influenza vaccine against melanoma, death in Florida from dengue virus infection and return of the virus to the US, wider use of the Ebola ERVEBO vaccine, before Dr. Griffin deep dives into recent statistics on RSV, influenza, SARS-CoV-2 infections and measles, the FDA-approved package inserts for the RSV biologic products, and the magnitude and durability of the immune response following administration of the COVID-19 vaccine in children.

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• Syrian Arab Republic launches coordinated public health response following poliovirus detection in Deir Ezzor (WHO)
• The U.S. Has Lost Its Measles-Elimination Status, Data Suggests (NY Times)
• Intralesional Influenza Vaccine for the Treatment of Stage I-IV Melanoma (Clinical Trials.gov)
• 501 Phase 1b trial of intratumoral administration of the seasonal influenza vaccine in patients with melanoma (BMJ Journals: Journal for ImmunoTherapy of Cancer)
• Why the simple flu shot could be a surprise weapon against cancer (Washington Post)
• Dengue (WHO: Dengue)
• Her Death From Dengue May Signal That the Disease Is Here to Stay (NY Times)
• Why H5N1 in mink is concerning (JPWeiland: X)
• Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service)
• CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newsroom)
• Ebola DRC (X)
• Ebola dashboard (ebola.fyi)
• EBOLA: The Democratic Republic of the Congo, 2026 (WHO)
• Wider use of Ervebo vaccine urged as DR Congo Ebola outbreak nears 11,000 cases (CIDRAP)
• Wastewater for measles (WastewaterSCAN)
• Impact of a large measles outbreak associated with transmission in the Americas and Canada's loss of measles elimination status: descriptive cohort study (the bmj)
• In America's measles epidemic, RFK Jr. is now on trial (Politico)
• Measles cases and outbreaks (CDC Rubeola)
• Measles Dashboard (South Carolina Department of Public Health)
• Utah measles outbreak response (Utah Department of Health and Human Services)
• Utah Measles Dashboard (Utah Department of Health and Human Services)
• Measles (VDH: Virginia Department of Health)
• Tracking Measles Cases in the U.S. (Johns Hopkins)
• New Measles Dashboard (Hospital + HealthSystem Association of Pennsylvania)
• Measles (Commonwealth of Pennsylvania)
• Measles Dashboard (New York State: Department of Health)
• Weekly measles and rubella monitoring (Government of Canada)
• Measles (WHO)
• Get the FACTS about measles (NY State Department of Health)
• Measles (CDC Measles (Rubeola))
• Measles vaccine (CDC Measles (Rubeola))
• Presumptive evidence of measles immunity (CDC)
• Contraindications and precautions to measles vaccination (CDC)
• Adverse events associated with childhood vaccines: evidence bearing on causality (NLM)
• Measles Vaccination: Know the Facts (IDSA: Infectious Diseases Society of America)
• Deaths following vaccination: what does the evidence show (Vaccine)
• Laboratory Testing for Measles (CDC: Measles (Rubeola))
• Measles Clinical Diagnosis Fact Sheet (CDC: Measles (Rubeola))
• Measles Serology Testing (CDC: Measles (Rubeola))
• New York State Seasonal Respiratory Virus Dashboard (New York State: Department of Health)
• Four Medical Societies, in Panel Led by UMSOM Expert, Back One Set of Flu, RSV and COVID-19 Vaccine Recommendations (University of Maryland: School of Medicine)
• Influenza: Waste water scan for 11 pathogens (WastewaterSCAN)
• US respiratory virus activity (CDC Respiratory Illnesses)
• Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA)
• WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP)
• FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP)
• Weekly surveillance report: cliff notes (CDC FluView)
• OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza)
• RSV: Waste water scan for 11 pathogens (WastewaterSCAN)
• Respiratory Diseases (Yale School of Public Health)
• US respiratory virus activity (CDC Respiratory Illnesses)
• RSV-Network (CDC Respiratory Syncytial virus Infection)
• Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV))
• Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP)
• BEYFORTUS (FDA: package insert)
• ENFLONSIA (FDA: package insert)
• AREXVY (FDA: package insert)
• ABRYSVO (FDA: package insert)
• MRESVIA (FDA: package insert)
• Effectiveness of the mRNA-1345 Vaccine Against Respiratory Syncytial Virus in US Veterans (JAMA Network Open)
• Waste water scan for 11 pathogens (WastewaterSCAN)
• COVID-19 deaths (CDC)
• Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses)
• COVID-19 national and regional trends (CDC)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Moderna Receives U.S. FDA Approval for Updated 2026-2027 COVID-19 Vaccines (Moderna)
• Novavax's Partnership Strategy Continues to Deliver with XFG-adapted Nuvaxovid™ Approvals in the U.S., EU and Japan for 2026-2027 Vaccination Season (novavax)
• Pfizer and BioNTech Receive U.S. FDA Approval for XFG-adapted COVID-19 Vaccine (Pfizer)
• FDA approves new COVID vaccines (CIDRAP)
• Coronavirus Disease 2019 (COVID-19) Hospitalization Surveillance Network (COVID-NET) (CDC: COVID)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIVYD)
• Infusion center (Prime Infusions)
• The magnitude and durability of immune response to the SARS-CoV-2 vaccination among children (Journal of the Pediatric Infectious Diseases Society)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Drug interaction checker (University of Liverpool)
• Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro)
• Understanding Coverage Options (PAXCESS)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• Managing healthcare staffing shortages (CDC)
• Anticoagulation guidelines (hematology.org)
• Daniel Griffin's evidence-based medical practices for long COVID (OFID)
• Long COVID hotline (Columbia: Columbia University Irving Medical Center)
• The answers: Long COVID
• Letters read on TWiV 1374
• Timestamps by Jolene Ramsey. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Content in this podcast should not be construed as medical advice.