In this episode, Prof Chapman explains what it means when embryos repeatedly fragment across multiple IVF cycles, and how to work out whether the cause lies with the lab, the sperm or the egg. He shares how the timing of fragmentation can point towards sperm DNA issues, why egg quality is the more common culprit even in younger women, and how a specialised polarised light technique lets his team look inside the egg to see the meiotic spindle. Drawing on a decade of his own research, Prof Chapman explains why this insight can finally give patients a clear answer before their next attempt.
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