In this episode, Prof Chapman is joined by fertility nurse Natalie to answer one of the most common questions from listeners: what should you do when you’re in your 40s and cycle after cycle isn’t working? Natalie explains why going back to basics matters — reviewing your initial workup, checking whether tests like AMH and antral follicle counts need repeating, and looking at inflammatory markers that may be overlooked. She walks through what a thorough second opinion involves, from treatment protocols and medication dosages to egg numbers, insemination methods and blastocyst outcomes, and why genetic testing (PGT-A) is often never discussed despite being valuable. If you’re wondering whether to push on or pause and reassess, this episode is for you.

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