How AI Shifts the Offense-Defense Balance in Biosecurity (with Paul-Enguerrand Fady)

Paul-Enguerrand Fady is a Senior Biosecurity Policy Manager at the Centre for Long-Term Resilience. He joins the podcast to discuss how AI is changing biosecurity. We cover how new tools could help defenders develop vaccines and diagnostics while also lowering barriers to misuse, and how managed access, know-your-customer checks, and DNA synthesis screening can reduce risk. The conversation also examines mirror life, medical supply chains, stockpiles, and why governments should plan ahead of crises.

LINKS:

• Centre for Long Term Resilience

• Paul-Enguerrand Fady Profile

CHAPTERS:

(00:00) Episode Preview

(01:11) Offense-defense balance basics

(11:13) Defensive AI opportunities

(19:24) Model release and evals

(25:59) DNA synthesis screening

(36:14) Screening incentives and infohazards

(46:36) Liability and mandates

(52:37) Mirror life risks

(01:03:28) Persistence and incentives

(01:10:18) Mirror life governance

(01:20:42) Supply chain lessons

(01:30:11) Stockpiling medical countermeasures

(01:37:58) Reshoring critical supplies

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