In this episode of Real-Life Science, we explore how mental fatigue may relate to your brain age rather than chronological age. Discover how brain scans reveal differences in fatigue development, what this means for aging, and practical steps you can take to manage cognitive tiredness in daily life. Join us for insights that connect scientific research with real-life decisions about your brain health.

READ the full study, “The differential effect of chronological age and brain age on cognitive fatigue: new metrics, new insights,” in the Journal of Neurology (2026), doi.org/10.1007/s00415-025-13584-1

LEAD INVESTIGATOR: Glenn R. Wylie, DPhil, https://kesslerfoundation.org/about-us/foundation-staff/glenn-wylie-dphil

LEARN about our Rocco Ortenzio Neuroimaging Center, https://kesslerfoundation.org/research/rocco-ortenzio-neuroimaging-center

READ all our Real-Life Science summaries, https://kesslerfoundation.org/newsletter/real-life-science

LISTEN to all our Real-Life Science summaries, soundcloud.com/kesslerfoundation/sets/real-life-science

PARTICIPATE: Interested in participating in our research remotely or in-person? Go to https://kesslerfoundation.org/join-our-research-studies

Production Notes This podcast was recorded, produced, and edited by Joan Banks-Smith, Sr. Creative Producer at Kessler Foundation (May 2026).

Accessibility Kessler Foundation uses AI voices and narrators to make our media more accessible. These tools help ensure people with visual or cognitive impairments can access our materials. Automated voices may not always capture intonation or pronunciation as clearly as the accompanying text. If you experience issues with our AI narrators, please contact us at communications@kesslerfoundation.org.

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