Peter Attia, MD is a highly respected expert in preventive medicine, focused on the crucial subject of longevity and cardiovascular health. He's also the author of the NY Times best selling book Outlive - which I highly recommend if you have not read it already. Peter's philosophy transcends the conventional goal of merely extending lifespan; it's about enriching the quality of every year, ensuring that each stage of life is lived with optimal health and vitality.
In this episode, we discuss:
(00:07:36) Defining cardiovascular disease
(00:09:43) Coronary plaque and fatality risk
(00:11:09) What is cholesterol?
(00:13:34) How ApoB predicts heart disease
(00:21:34) Factors elevating ApoB
(00:25:24) ApoB reference range explained
(00:27:23) Does high ApoB cause cardiovascular disease
(00:37:01) ApoB thresholds for ASCVD prevention
(00:40:27) Dietary factors raising ApoB
(00:39:33) Genetics of ApoB and LDL
(00:53:24) Does low LDL increase cancer?
(00:56:19) Cholesterol-lowering drugs
(00:59:59) Statins, uses, and side effects
(01:03:12) Are statins toxic to mitochondria?
(01:09:56) Ubiquinol for statin-induced muscle soreness
(01:11:09) How to train in zone 2
(01:17:09) Statins and neurodegenerative disease risk
(01:21:54) Cholesterol synthesis in the brain (desmosterol role)
(01:25:58) Statin alternatives – pros and cons
(01:27:30) Ezetimibe
(01:31:01) Bempedoic acid
(01:36:49) Berberine for CVD Risk Reduction?
(01:39:36) Muscle as a glucose sink
(01:45:58) Chronic glucose toxicity and vascular impact
(01:51:38) Hemoglobin A1C Levels and Mortality Data
(01:55:35) 80/20 Zone 2/VO2 Max Training Protocol
(02:02:12) Insights from VO2 max testing data
(02:12:17) How obesity increases cancer risk
(02:15:03) Cancer screening benefits and risks
(02:20:47) Dr. Attia's recommended cancer screening age
(02:28:54) Liquid biopsies for detecting cancer
(02:34:48) CT scans, mammograms and radiation concerns
(02:40:32) Menopause – hormonal shifts and health effects
(02:45:13) Hormone replacement therapy (HRT)
(02:58:57) Perimenopause diagnosis with hormone levels
(03:02:04) HRT's impact on dementia, cancer, and heart disease risk
(03:04:49) Estrogen's role in bone density
(03:07:42) Vitamin D
(03:16:24) Testosterone replacement for women's sexual function
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