Despite the well-publicised success of global smallpox eradication, 'zero' remains an elusive goal for the majority of vaccine-preventable diseases, making reduced pathogen circulation, or direct protection of the vulnerable more achievable strategies. We will consider potential deleterious consequences of reduced infection transmission, in the context of diseases such as influenza and pertussis, where immunity following natural exposure may be superior to that following immunisation. Implications for vaccine design and implementation will be discussed. This seminar was delivered by Dr Jodie McVernon: Programme Leader, Mathematical Modelling. Deputy Head, Vaccine and Immunisation Research Group, Melbourne School of Population Health, Australia. Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/
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