Covid autoimmunity

Covid toe, caused by the immune response to the virus, not the virus itselfUploaded 08-10-21https://covidskinsigns.comhttps://onlinelibrary.wiley.com/doi/full/10.1111/bjd.20707ObjectivesTo study skin and blood endothelial and immune system activationIn chilblain-like lesions (CLL),CLL in comparison with healthy controls and seasonal chilblains (SC)(cold-induced sporadic chilblains occurring during 2015 and 2019)MethodsObservational studySaint-Louis Hospital, Paris, FranceN = 50Cytokine assaysAssessment of interferon-stimulated gene expression in whole bloodSoluble markers of endothelial activation and/or angiogenesisHistological examinationsLateral flow spike assayCirculating endothelial cell countingStatistical analysisResultsHistological patterns were similar in CLL and SC groupsTranscriptomic signatures overlapped in both the CLL and SC groupsType I interferonCytotoxic–natural killer gene signatureCLL were characterized by higher IgA tissue depositionMore complement and angiogenesis factors in CLL compared with SCAutoimmune vasculitisConfirmed endothelial dysfunction in CLLMicroangiopathy leading to clinical chilblainsDisrupt the thrombo-protective state of endothelial cellsLikely contributing to microvascular thrombosisSystemic endothelial activation?The PT ratio and aPTT were normal in all patientsOnly three patients (6%) had a moderate increase in D-dimer levelsConclusionsInflammation in the skin in CLLAssociated with endothelial alterationImmune infiltration of cytotoxic and type I IFN-leading to clinical manifestationshttps://www.bbc.co.uk/news/health-58801462UK podiatrist Dr Ivan Bristowlike the regular chilblains typically seen during cold spells and in people who have problems with circulation - the lesions usually go away on their own. But some may need treatment with creams and other drugs.The confirmation of the cause will help to develop new treatments to manage it more effectivelyDr Veronique Bataille, consultant dermatologist, British Skin FoundationCovid toe was seen very frequently during the early phase of the pandemic, but has been less common in the current Delta variant wave.That might be down to more people being vaccinated or having some protection against Covid from past infections. Presentations after vaccination are much rarerDelayed presentation my mean link is missedFree download my two comprehensive but free educational text books (over 50,000 downloads so far) or make a donation to the campbellteaching project using this link: http://159.69.48.3 Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices