33% reduction in hospitalization with acute respiratory infections, (upper and lower)
Covid
Influenza
Bronchitis
Pneumonia
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Vitamin D deficiency linked to hospital admissions
https://www.bbc.com/news/articles/czx3g1d57xpo
University of Surrey
People with a severe vitamin D deficiency (below 15 nmol/L), a third more likely to be admitted to hospital with conditions including bronchitis and pneumonia.
(15 nmol/L is 6 ng / ml)
Abi Bournot, (lead author)
"antibacterial and antiviral properties" of vitamin D are thought to help reduce the risk of respiratory tract infections."
Improves immune recognition
Supports T and B cell response
Reduces excessive pro-inflammatory cytokines
Promotes production of antimicrobial peptides against bacterial infections.
Enhances antiviral white cell function, e.g. promotes interferon reserves
"This research attaches hard data to support the theory.
"Despite its importance to our overall health, many people are deficient and do not meet the government's recommended intake of 10 microgrammes of vitamin D per day."
(10 micrograms is 400 iu)
NHS data from 36,258 people. (40 to 69)
For each 10 nmol/l (4 ng / ml) increase in vitamin D,
the hospital admission rate for respiratory tract infections fell by 4%.
Association between serum 25-hydroxyvitamin D status and respiratory tract infections requiring hospital admission: unmatched case-control analysis of ethnic groups from the United Kingdom Biobank cohort
https://www.sciencedirect.com/science/article/abs/pii/S0002916525007713?via%3Dihub
Background
Vitamin D status has been found to be inversely associated with risk of respiratory tract infections (RTIs).
Methods
An unmatched case-control study (Observational, cases are not individually matched on specific characteristics)
Data from United Kingdom Biobank
Includes 500k adults with serum 25(OH)D status and hospital episodes
N = 36,258, n = 27,872
Results
34% were White
28% Asian
19% Black
11% other
7% of mixed ethnicity.
RTI rate was 8.5%
(median time to RTI, 14.8 y)
Each 25(OH)D +10 nmol/L increase) was significantly associated with a 4% lower hazard ratio (HR) for RTI hospitalization.
(So difference between 15 nmol/L and 65 nmol/L would be 50% reduction)
less than15 nmol/L v more than 75 nmol/L 33% reduction in hospitalization with acute respiratory infections
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