Every nephrologist knows about serum creatinine, eGFR, albuminuria, proteinuria. We use them to assess disease activity. But do we really assess disease activity with them? eGFR can be low and albuminuria or proteinuria can be high because of chronic and potentially irreversible changes, like glomerulosclerosis and tubulointerstitial fibrosis, changes that might not be amenable to treatment. How do we know which patient needs more treatment if what we are picking up with established markers m...
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