Abstract: To understand the plasticity of cells and their responses to molecular perturbations, such as drugs or developmental signals, it is vital to recover the underlying population dynamics and fate decisions of single cells. However, measuring features of single cells requires destroying them. As a result, a cell population can only be monitored with unpaired sequential snapshots. In order to reconstruct individual cell fate trajectories, as well as the overall dynamics, one needs to re-align these unpaired snapshots, in order to guess for each cell what it might have become at the next step...
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