Amyloidosis

Ninja Nerds,

Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Amyloidosis, a complex disorder characterized by the misfolding and deposition of insoluble amyloid fibrils in tissues. We break down the different subtypes, including AL (light chain), AA (secondary), ATTR (transthyretin), and Aβ2M (β2 microglobulin), highlighting their unique pathogenesis, clinical manifestations, and diagnostic approaches.

Our discussion covers the systemic vs. localized forms of the disease, exploring how amyloid deposition can impact critical organs like the heart (restrictive cardiomyopathy), kidneys (nephrotic syndrome), nervous system (autonomic and peripheral neuropathy), and gastrointestinal tract. We also walk through essential diagnostic tools, including serum and urine electrophoresis, fat pad biopsy with Congo red staining, mass spectrometry, and advanced imaging techniques like cardiac MRI and PYP scanning for ATTR amyloidosis.

Finally, we break down the latest treatment strategies, from chemotherapy and autologous stem cell transplant for AL amyloidosis. Whether you’re preparing for exams, rotations, or just want to master this challenging topic, this episode is packed with high-yield insights to boost your understanding!

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