Ep. 95: “Lymphocyte Signaling” Featuring Dr. Gail Bishop

Dr. Gail Bishop is a Professor of Microbiology and Immunology at the University of Iowa, where her lab studies the molecular mechanisms underlying lymphocyte activation and tolerance.  She talks about TRAF signaling, the NFκB pathway, and effects on B and T lymphocytes. She also discusses her role as Editor-in-Chief of The Journal of Immunology.

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Pyroptotic Cell Corpses – Cells assemble filopodia before cell rupture to serve as a posthumous mark for a cell that has died by gasdermin-induced pyroptosis.

Engineering Synthetic T Cell Receptors – T-Switch identifies therapeutic TCR variants with enhanced potency and specificity.

Macrophages in Muscle – Macrophages in muscle spindles express the machinery for synthesizing and releasing glutamate.

Synthetic Suppressor T Cells – Researchers engineered human T cells to make a synthetic receptor that recognized overactive T cells.

Image courtesy of Dr. Gail Bishop