In this episode of The Metabolic Classroom, Dr. Bikman introduces the concept of the Randle Cycle, also known as the glucose fatty acid cycle, in a lecture aimed at providing a better understanding of metabolism. The Randle Cycle, first identified by Dr. Philip Randle and his colleagues in the 1960s, explores how cells decide between using glucose or fatty acids for fuel. Dr. Bikman emphasized that this cycle has been misinterpreted on social media and aims to clarify its relevance in metabolic functions and nutritional decisions.
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00:00 - Introduction to the Metabolic Classroom and Dr. Ben Bikman
01:00 - Overview of the Randle Cycle (Glucose Fatty Acid Cycle)
02:00 - Historical Background: Philip Randle’s Research
03:00 - Experimental Model: Perfused Rat Hearts
04:00 - Key Terms: Glucose and Fatty Acids
05:00 - Concept of Substrate Competition
06:00 - Reciprocal Inhibition: Fats vs. Glucose
08:00 - Fatty Acid Oxidation Process
10:00 - Biochemical Pathways: Acetyl-CoA, NADH, and Pyruvate Dehydrogenase
12:00 - Role of Citrate in Glycolysis Inhibition
14:00 - Glucose Utilization and Malonyl-CoA
16:00 - Insulin’s Role in Fuel Selection
18:00 - Insulin’s Impact on Glucose and Fat Burning
20:00 - Diabetes Case Study: Type 1 and Type 2
22:00 - Type 1 Diabetes: High Glucose and Fatty Acids
24:00 - Ketones Production in the Liver
26:00 - Type 2 Diabetes: Insulin Resistance and Metabolic Inflexibility
28:00 - Insulin Resistance in Fat Cells
30:00 - Metabolic Inflexibility in Type 2 Diabetes
32:00 - Insulin Resistance in the Brain
34:00 - The Impact on Hunger and Neurological Disorders
36:00 - Conclusion: Importance of Insulin in Metabolic Health
#Metabolism #RandleCycle #DrBenBikman #InsulinResistance #GlucoseMetabolism #FattyAcidOxidation #MetabolicHealth #DiabetesResearch #Ketosis #Type1Diabetes #Type2Diabetes #InsulinRole #CellBiology #NutritionalScience #MetabolicFlexibility #Ketones #GlucoseUtilization #FatBurning #BiomedicalScience #HealthLecture
My favorite meal-replacement shake: https://gethlth.com (discount: BEN10)
My favorite electrolytes (and more): https://redmond.life (discount: BEN15)
My favorite allulose source: https://rxsugar.com (discount: BEN20)
References:
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/randle-cycle
Insulin Regulation of Ketone Body Metabolism: https://onlinelibrary.wiley.com/doi/10.1002/0470862092.d0308
The Effects of a Ketogenic Diet and Exercise Interventions on Cognitive Function: https://faseb.onlinelibrary.wiley.com/doi/10.1096/fasebj.31.1_supplement.lb810
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