This talk will review current evidence on the prevalence and manifestations of post-intensive care (PICS) and post-sepsis syndrome (PSS) and will explore links with prolonged critical illness and post-COVID19 syndrome. Current advances in our understanding of the pathophysiology of PICS will be discussed, including the role of immune and macrophage dysfunction, as well as their implications for the management of PICS. Evidence on approaches to improve long-term outcomes after critical illness will be presented, and gaps in the literature and practice implications will be discussed.

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