0:00 Introduction
1:29 Ness’ journey to becoming an entrepreneur and first-time founder.
5:37 Discussing CRISPR Therapeutics and its application in treating sickle cell disease.
7:43 Exploring the potential of RNA therapies and Ness’ work at Korro Bio.
11:29 Balancing scientific discovery with commercial viability in alpha-1 antitrypsin therapies for lung and liver diseases.
14:55 Creating a vision, setting realistic goals, and managing capital in early-stage biotech companies.
19:42 Differentiating biotech companies that use the same platform technologies, such as RNA editing.
24:19 Addressing regulatory barriers in drug development and exploring phenotypic manifestations of diseases.
28:53 Discussing bottlenecks in biotechnology, including drug delivery, regulation, patient segregation, and reimbursement.
33:02 Exploring how to price cures based on the financial burden saved by the healthcare system.
35:31 Sharing insights on Khosla Ventures’ investment in OpenAI and the impact of AI in biotech.
41:28 Discussing the role of AI in identifying drug targets, increasing impact rates, and enhancing patient safety.
46:23 Discovering what advancements in biotechnology Ness is most excited about.
51:40 Closing remarks.
