Kiran Krishnan on How to Build a Resilient Microbiome

Food Scientist and Registered Nutritionist, Kriben Govender (Honours Degree in Food Science & Technology) has an insightful conversation with Chief Scientific Officer of Microbiome Labs, Kiran Krishnan on How to build a resilient microbiome, metabolic endotoxemia (leaky gut), the negative impact of lipopolysaccharides (LPS), the diabetes pandemic, probiotics for optimal health, spore-based probiotics, postbiotics, butyrate and acne control, keystone bacteria in the gut and much more        Bio:    Kiran Krishnan is a Research Microbiologist and has been involved in the dietary supplement and nutrition market for the past 17 years. He comes from a strict research background having spent several years with hands-on R&D in the fields of molecular medicine and microbiology at the University of Iowa.  He is currently involved in 9 novel human clinical trials on probiotics and the human microbiome. Kiran is also on the Scientific Advisory Board for 5 companies in the industry. Kiran offers his extensive knowledge and practical application of the latest science on the human microbiome as it relates to health and wellness.       Topics discussed:  

• Kiran’s origin story
• What does good gut health look like?
• The concept of “resilience” in gut health
• What about different dietary regimes like paleo, vegan, carnivore etc?
• Human evolution of omnivores
• Gut sensitivity in the modern world
• How to foster resilience
• The concept of “Holobiome"
• Living in an antibiotic laden world
• Exposure from personal care products
• Maximising exposure to environmental microbes
• Allergies, Asthma and the microbiome
• Diversity of diet like our ancestors
• Spore based bacteria
• Metabolic endotoxemia (leaky gut) and chronic disease 
• Lipopolysaccharides, Gram-Positive and Gram-Negative Bacteria
• Sepsis and bacteraemia signalling
• LPS and Chronic inflammation, Rheumatoid Arthritis, Anxiety and Depression, Alzheimer's 
• LPS toxicity and bacterial types
• LPS and Diabetes Risk
• LPS mechanism on impairing blood sugar modulation
• The impact of C-section on gut microbiome composition 
• Antibiotics and the microbiome
• What is a probiotic organism?
• Where do probiotics come from?
• The origin of Spore based probiotics
• What are spore-based bacteria?

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• The gastric barrier, bile salts and pancreatic enzymes 
• Short Chain Fatty Acids, Postbiotics and Metformin
• Butyrate and insulin sensitivity
• Butyrate and acne control 
• Oligosaccharide based prebiotics- FOS, GOS, XYLO

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• Keystone Species in the Microbiome: Akkermansia, Faecalibacterium, Bifidobacteria, Ruminocococus 
• The benefits of dead bacteria (biological response modifiers), BLP1, Micro RNA, Microvesicles 
• Intra- kingdom communication and gene expression
• The importance of subspecies classification and associated health benefits
• The science of postbiotics and AMUC 
•  Megasporebiotic and Leaky Gut

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Microbiome Stool Testing, Deuterium Testing and Nutritional Consulting

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    Connect with Kiran Krishnan   Website- https://microbiomelabs.com/       Connect with Kriben Govender:    Facebook- https://www.facebook.com/guthealthgurus Instagram- https://www.instagram.com/guthealthgurus Youtube- https://www.youtube.com/c/Nourishmeorganics?sub_confirmation=1 Gut Health Gurus Facebook Group: https://www.facebook.com/groups/nourishmeorganics/ Deuterium Depletion Support Facebook Group: https://www.facebook.com/groups/347845406055631/   Download links                 If you enjoyed this episode and would like to show your support:   1) Please subscribe on Apple Podcasts, give us 5 stars and leave a positive review     Instructions:   - Click this link  https://itunes.apple.com/au/podcast/gut-health-gurus-podcast/id1433882512?mt=2   - Click "View in Itunes" button on the left-hand side - This will open the Itunes app - Click the "Subscribe" button - Click on "Ratings and Reviews" tab - Click on "Write a Review" button   Non-Itunes users can leave a Google Review here: https://goo.gl/9aNP0V     2) Subscribe, like and leave a positive comment on Youtube   https://www.youtube.com/c/Nourishmeorganics?sub_confirmation=1   3) Share your favourite episode on Facebook, Instagram, and Stories 4) Let your friends and family know about this Podcast by email, text, messenger etc     Thank you so much for your support. It means the world to us.