In this episode of the podcast, Sam Harris speaks with Frank Wilczek about the fundamental nature of reality. They discuss the difference between science and non-science, the role of intuition in science, the nature of time, the prospect that possibility is an illusion, the current limits of quantum mechanics, the uncertainty principle, space-time as a substance, the “unreasonable effectiveness” of mathematics in science, the possibility that we might be living in a simulation, the fundamental building blocks of matter, the structure of atoms, the four fundamental forces, wave-particle duality, the electromagnetic spectrum, the many-worlds interpretation of quantum mechanics, the implications of infinite space-time, dark energy and dark matter, and other topics.

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