In this episode of Daily Value, we look at science of Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR), two NAD+ precursors gaining traction in longevity research. Both supplements aim to restore NAD+ levels, critical for energy metabolism and cellular repair, yet their distinct pathways and tissue-specific effects suggest considerations for choosing one over the other.

Discussion Points:

-The metabolic pathways of NMN and NR, highlighting how their mechanisms of action influence NAD+ synthesis across tissues.

-Insights from a 2024 study (in rodents - PMID: 38645109) demonstrating the dual effects of NMN: improvements in cardiac and liver function, alongside kidney inflammation linked to toxic metabolite accumulation at high doses.

-Clinical dosing strategies, safety considerations, and how age and tissue-specific needs may guide the choice between NMN and NR.

https://pubmed.ncbi.nlm.nih.gov/38645109/ 

https://iadns.onlinelibrary.wiley.com/doi/10.1002/fft2.511 

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