A potentially game-changing Covid antiviral pill developed by Pfizer has been authorized by the FDA. Paxlovid, which is proven to significantly reduce Covid hospitalizations and death, will be available in January and has also been green-lighted for children aged 12 and older.

Also tonight: school closures across the U.S. mount amid the Omicron surge, Biden reiterates his plans to run in 2024 saying a Trump rematch would "increase the prospect", when does tough on crime go too far? A truck driver is set to serve a 110-year prison sentence after a deadly crash in Colorado and Bob Costas joins to discuss vaccinations and sports leagues.

Guests: Dr. Peter Hotez, Joseph G. Allen, Bret Stephens and George Brauchler.

Hosted by Michael Smerconish.

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